A study published in the journal Obesity, investigated whether insulin resistance was a necessary precursor of weight gain induced by eight weeks of overeating in adults. There was a wide range of insulin sensitivity measured in the subjects at baseline and baseline insulin sensitivity level was not predictive of fat gain from overeating. This suggests that the insulin resistance found in obesity is more likely the result of the obesity than the cause of the obesity. Other studies have shown that exercise and physical activity increase insulin sensitivity even in obese subjects.
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